ABSTRACT
ObjectiveTo compare the efficacy and safety of pregabalin and gabapentin in treatment of patients with diabetic peripheral neuropathic pain.MethodsSixty patients with diabetic peripheral neuropathic pain were allocated into pregabalin group(30 cases ) and gabapentin group (30 cases) for a 4-week period treatment by random digits table method.The efficacy was measured with visual analogue scale (VAS) score,while the side effects were evaluated.ResultsVAS score in both groups was significantly lower at the end of 1st,2nd or 4th week after treatment than that before treatment [pregabalin group:( 4.05 ±0.93),(2.73 ±0.72),(2.06 ±0.58) scores vs.(7.45 ±0.82) scores; gabapentin group:(5A2 ±0.88),(2.93 ± 0.80),(2.19 ± 0.64) scores vs.(7.68 ± 0.84) scores] (P ＜ 0.01 ).VAS score in pregabalin group was lower than that in gabapentin group at the end of 1st week significantly (P＜ 0.01 ).Not only there was no significant difference in VAS score at the end of 2nd or 4th week between two groups,but also in response rates at the end of 4th week (P ＞ 0.05 ).The rate of adverse reaction in pregabalin group was significantly lower than that in gabapentin group [16.67％ (5/30) vs.36.67％( 11/30)] ( P ＜ 0.01 ).ConclusionPregabalin is as effective as gabapentin in treatment of patients with diabetic peripheral neuropathic pain,but it has faster effect and less adverse events than gabapentin.
ABSTRACT
Objective: To explore the changes of pulmonary function in type 2 diabetes and its related factors.Methods: The pulmonary functions of 72 patients with type 2 diabetes and 22 healthy objects were measured,and the related factors,such as duration of DM,HbA1c,BMI,were analysed with linear regression analysis.Ninteen of them underwent a 12-week-long intensive insulin therapy and pulmonary function tests before and after the treatment.Results: Vital capacity(VC),forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),total lung capacity(TLC) and carbon monoxide diffusion in the lung(DLco) were significantly decreased in the diabetes patients.Correlation analysis revealed that DLco was negatively correlated with the duration of DM.which was shown by linear regression analysis to be the only significant predictor.After a 12-week-long intensive insulin therapy,DLco and DLco/VA decreased significantly.Conclusion:Patients with type 2 diabetes have abnormal pulmonary ventilatory function and impaired pulmonary diffusive function,and the latter is related to the time of hyperglycemia,and can not ameliorated by short-term glycemic control.